Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EIF2AK3 (PERK) and EIF2B complex: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| PARP1 and XRCC1 | co_associated_with | gene | 0.40 |
| SOX10 and DLX1/2 | co_associated_with | gene | 0.40 |
| SYN1, SLC1A2, and CX3CR1 | co_associated_with | gene | 0.40 |
| TREM2 and C3 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | co_associated_with | gene | 0.40 |
| BMP4 and BMPR1A | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Neuronal Integrated Stress Response Modulation | 0.452 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||